The treatment of hyperphosphataemia in CKD: calcium-based or calcium-free phosphate binders?
نویسندگان
چکیده
منابع مشابه
Differences in gastrointestinal calcium absorption after the ingestion of calcium-free phosphate binders.
Both calcium-containing and noncalcium-containing phosphate binders can increase gastrointestinal calcium absorption. Previously, we observed that lanthanum carbonate administration to rats with renal failure is not associated with increased calciuria. Additionally, lanthanum carbonate treatment in dialysis patients has been associated with a less pronounced initial decrease in serum parathyroi...
متن کاملCalcium-based phosphate binders are appropriate in chronic renal failure.
Many nephrologists feel threatened by the allegation that, in patients with chronic renal failure, treatment with calcium-based phosphate binders (calcium acetate and calcium carbonate) may induce coronary artery and cardiac calcification, thereby imposing a greater risk for death compared with sevelamer, a non-calcium-based binder. Acknowledging that drug manufacturers are not unaware of the m...
متن کاملPhosphate binders in CKD: bad news or good news?
Hyperphosphatemia has long been considered an important contributor to the mineral and bone disorder associated with CKD (CKD-MBD). Already 50 years ago, Slatopolsky et al. showed that as GFR decreased, fractional phosphate excretion rose because of inhibition of tubular phosphate reabsorption by parathyroid hormone (PTH), thus preventing serum phosphorus to rise. In the last 10 years, fibrobla...
متن کاملThe effects of non-calcium-based phosphate binders versus calcium-based phosphate binders on cardiovascular calcification and bone remodeling among dialysis patients: a meta-analysis of randomized trials.
BACKGROUND Vascular calcification significantly increases the rates of cardiovascular mortality in hemodialysis (HD) patients. Abnormalities in mineral metabolism may play a role in the pathogenesis of arterial calcification. Whether patients treated with non-calcium-based phosphate binders had reduced aortic vascular calcification compared to those treated with calcium-based phosphate binders ...
متن کاملEffects of phosphate binders in moderate CKD.
Some propose using phosphate binders in the CKD population given the association between higher levels of phosphorus and mortality, but their safety and efficacy in this population are not well understood. Here, we aimed to determine the effects of phosphate binders on parameters of mineral metabolism and vascular calcification among patients with moderate to advanced CKD. We randomly assigned ...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2010
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfq691